刘家玲 饶兴愉

赣南医科大学第一附属医院

摘要(Abstract)：

钙离子（Ca²⁺ ）是人体内不可或缺的重要物质，在哺乳动物细胞中作为第二信使，参与几乎所有细胞过程的调节，其对病 原体存活及毒力的重要性已得到公认。维生素D与钙的关联极为密切，一方面可提升肠道对钙的吸收效率，另一方面能刺激骨骼中的 破骨细胞释放钙离子，进而增加骨骼的钙释放量。目前研究认为，钙在肺炎中可发挥炎症调节剂作用，参与炎症反应过程；维生素D 则不仅能抑制肺部炎症，还可通过显著影响炎症细胞功能，增强机体先天免疫防御能力。然而，二者在肺炎发生发展中更具体的潜 在作用机制仍不明确。基于此，本文将深入剖析钙及维生素D对炎症细胞的影响，及其在肺部疾病中的作用机制与治疗价值。

关键词(KeyWords)：

钙离子；维生素D；肺炎

参考文献(References)：

［1］Panfeng F ，Vijay M ，Syed M ，et al. Role of nicotinamide adenine dinucleotide phosphate-reduced oxidase proteins in Pseudomonas aeruginosa-induced lung inflammation and permeability.［J］.American journal of respiratory cell and molecular biology，2013，48（4）:477-88. 

［2］Shamim Q ，Samira A ，Rachel M ，et al.Ending preventable child deaths from pneumonia and diarrhoea by 2025. Development of the integrated Global Action Plan for the Prevention and Control of Pneumonia and Diarrhoea［. J］.Archives of disease in childhood，2015， 100 Suppl 1（Suppl 1）:S23-8. 

［3］Zhuokai Z ，Xiaolin W ，Meijin H ， et al.Serum calcium improved systemic inflammation marker for predicting survival outcome in rectal cancer.［J］.Journal of gastrointestinal oncology， 2021，12（2）:568-579. 

［4］Jun F ，Lin F ，Ying L ，et al.Reduction of lymphocyte count at early stage elevates severity and death risk of COVID-19 patients: a hospital-based case-cohort study.［J］.Archives of medical science: AMS，2023，19（5）:1303-1313. 

［5］Effat A ，Esmat A ，Masood Z ，et al.The effect of low serum calcium level on the severity and mortality of Covid patients: A systematic review and meta-analysis［. J］.Immunity，inflammation and disease， 2021， 9（4）:1219-1228. 

［6］ C H F T ，Dhanansayan S ，K D Z ， et al.A continuous fluorescence assay for the determination of calcium-dependent secretory phospholipase A2 activity in serum［. J］.Clinica chimica acta; international journal of clinical chemistry，2007，379（1-2）:119-26. 

［7］ Haoling W ，Dongqiong L ，Youli W ， et al.Clinical significance of serum S100 calcium-binding protein A12 concentrations in patients with community-acquired pneumonia. ［J］.The Journal of international medical research ， 2023 ， 51 （8）:3000605231191021-3000605231191021. 

［8］ Maheen S ，S. J M ，A. H A ， et al.Immune Modulatory E （ ff 9 e） cts :2 o8 f 7 V 9- it 2 am 87 in 9.D on Viral Infections.［J］.Nutrients，2020，12 

［9］Mariangela R ，Alessandra M ，Silvia L ， et al.Self-Care for Common Colds: The Pivotal Role of Vitamin D，Vitamin C，Zinc， and Echinacea in Three Main Immune Interactive Clusters （Physical Barriers，Innate and Adaptive Immunity）Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds.［J］.Evidence-based complementary and alternative medicine: eCAM，2018，20185813095. 

［10］Zheng J ，Science E A O O C G Y ，361005 X U X S L O S ， et al.Calcium-Rich Spirulina:A Potential Immunopotentiator And Calcium Supplemen［t C］//Engineering Technology Press，Hong Kong， Intelligent Information Technology Application Association， Hong Kong.Proceedings of 2008 International Seminar on Future BioMedical Information Engineering.，2008:364-367. 

［11］Shaniya A ，Shweta A ，Salman K ，et al.VITAMIND AND ITS THERAPEUTIC RELEVANCE IN PULMONARY DISEASES［J］. The Journal of Nutritional Biochemistry，2020，90108571. 

［12］Muhammad A ，Imran K ，A. F A ，et al. Current Overview on Therapeutic Potential of Vitamin D in Inflammatory Lung Diseases ［J］. Biomedicines， 2021，9（12）:1843-1843. 

［13］Luciano M R B C ，Max B ，E P M .The antiviral properties of vitamin C.［J］.Expert review of anti-infective therapy， 2020， 18 （2）:99-101. 

［14］Huawei W ，Yiming D ，Zhixin W ，et al.Serum Vitamin D Insufficiency in Hospitalized Full-Term Neonates at a Tertiary Hospital in Eastern China ［J］.Frontiers in Pediatrics， 2022， 10878992-878992. 

［15］ Haitchi S ， Moliterno P ， Widhalm K .Prevalence of vitamin D deficiency in seniors – a retrospective study［J］. Clinical Nutrition ESPEN， 2023.