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脐带间充质干细胞治疗恶性血液病研究进展

李文强 

赣南医科大学

摘要(Abstract):

脐带间充质干细胞(UC-MSCs)在再生医学领域具有重要价值,近年来被广泛应用于血液系统恶性肿瘤的治疗研究。这类 细胞在促进造血功能恢复、减轻移植物抗宿主反应、增强免疫功能等方面表现出显著效果。随着临床应用的不断推进,UC-MSCs在 恶性血液病治疗中的作用机制逐渐明晰,相关治疗方案持续改进。目前,该细胞疗法已成为血液病综合治疗的重要手段之一,为提 升患者生存质量和治疗效果带来了新的可能。本文围绕UC-MSCs的基本特性、在造血干细胞移植中的作用机制、针对各类恶性血液 病的临床应用现状,以及未来发展趋势与挑战展开探讨。


关键词(KeyWords):

脐带间充质干细胞;恶性血液病;造血干细胞移植;移植物抗宿主病;免疫调节


参考文献(References):

[1]Limin L ,Yanming Z ,Wenjing J , et al.Combination of haploidentical haematopoietic stem cell transplantation with an unrelated cord-blood unit in patients with severe aplastic anemia: a report of 146 cases.[J]. Bone marrow transplantation, 2020, 55 (10):2017-2025. 

[2]Qiu-Ling W ,Xiao-Yun L ,Di-Min N , et al.Umbilical cord blood-derived mesenchymal stem cells ameliorate graft-versus-host disease following allogeneic hematopoietic stem cell transplantation through multiple immunoregulations.[J]. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,2015,35(4): 477-84. 

[3]Niu W J ,Li Y ,Xu C ,et al.Human umbilical cord-derived mesenchymal stromal cells for the treatment of steroid refractory grades Ⅲ -IV acute graft-versus-host disease with long-term follow-up[J].Frontiers in Immunology,2024,151436653-1436653. [4]张晓婷.非血缘供者异基因外周血造血干细胞联合脐带 间充质干细胞移植治疗恶性血液病临床研究[D].大连医科大学, 2015.

[5]YuanFF,FuYW,ZhaoMY,LiMH,LiGP,WeiXD.[Efficacyandsafetyanalysis ofumbilicalcordbloodcombinedwithhaploidhematopoieticstemcelltransplantationinthetreatmentof malignanthematologicalmalignancies].ZhonghuaYiXueZaZhi.2023Sep19;103(35):2778-2785. Chinese.

[6]吴亚妹,曹永彬,李晓红,等.脐带间充质干细胞联合 单倍体异基因造血干细胞移植治疗 36 例难治/复发髓细胞白血病 临床疗效[J].中国实验血液学杂志,2014,22(04):1053-1057. [7]Ruihao H ,Ting C ,Sanbin W ,et al.Mesenchymal Stem Cells for Prophylaxis of Chronic Graft-vs-Host Disease After Haploidentical Hematopoietic Stem Cell Transplant: An Open-Label Randomized Clinical Trial[J]. JAMA Oncology,2023,

[8] Wang J ,Li X ,Liu P , et al.A phase 2 pilot study of umbilical cord blood infusion as an adjuvant consolidation therapy in elderly patients with acute myeloid leukemia[J]. Signal Transduction and Targeted Therapy, 2024, 9(1):358-358.

[9] Yao H ,Huang R ,Fu H , et al.Sequential Infusion of Mesenchymal Stem Cell for Graft-Versus-Host Disease Prevention in Haploidentical Hematopoietic Stem Cell Transplantation: An Open-Label,Multicenter,Randomized Controlled Clinical Trial[. J]. Journal of clinical oncology : official journal of the American Society of Clinical Oncology,2025,JCO2402119. 

[10] Chen Z , Yang C , Ji J , et al.Umbilical Cord Blood-Derived Cells Can Reconstruct Hematopoiesis in an Aplastic Anemia Animal Model. [J]. Stem cells international , 2024 , 20244095268.

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